Arhgap1 Rho GTPase activating protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap1provided by RGD
Official Full Name: Rho GTPase activating protein 1provided by RGD
Primary source: RGD:1306068
See related: Ensembl:ENSRNOG00000016610 AllianceGenome:RGD:1306068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in endosomal transport; negative regulation of endocytic recycling; and transferrin transport. Predicted to act upstream of or within regulation of GTPase activity and small GTPase mediated signal transduction. Located in perinuclear region of cytoplasm. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 250.8), Heart (RPKM 143.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (98077064..98099163)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (77621377..77643400)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (80555196..80576881)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of ARHGAP1 as a result of hypoxic conditions in the cellular and rat models was observed. ARHGAP1 was also shown to initiate the apoptosis pathway by regulating the cell death modulators B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein.
Title: Rho GTPase‑activating protein 1 promotes apoptosis of myocardial cells in an ischemic cardiomyopathy model.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127727 (e-PCR)
- UniSTS:211037

RH142167 (e-PCR)
- UniSTS:231419

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in sorting endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107747.2 → NP_001101217.2 rho GTPase-activating protein 1

See identical proteins and their annotated locations for NP_001101217.2

Status: VALIDATED

Source sequence(s)

AA900696, CK480577, CO573331, DN932805, DV725096, EV768858

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

98077064..98099163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104900.2 → XP_038960828.1 rho GTPase-activating protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234551.4 → XP_006234613.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234613.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Related

ENSRNOP00000059324.1

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234560.4 → XP_006234622.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234622.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Related

ENSRNOP00000070761.2

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234556.4 → XP_006234618.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234618.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Related

ENSRNOP00000087093.1

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_039104901.2 → XP_038960829.1 rho GTPase-activating protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234554.4 → XP_006234616.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234616.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234558.5 → XP_006234620.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234620.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234552.5 → XP_006234614.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234614.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234557.5 → XP_006234619.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234619.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_017591716.3 → XP_017447205.1 rho GTPase-activating protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234553.5 → XP_006234615.1 rho GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234615.1

UniProtKB/TrEMBL

A0A8I6A7T6, D4A6C5

Conserved Domains (2) summary

cd04404
Location:239 → 431

RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...

pfam13716
Location:82 → 216

CRAL_TRIO_2; Divergent CRAL/TRIO domain
XM_006234559.4 → XP_006234621.1 rho GTPase-activating protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A7T6

Conserved Domains (2) summary

cd04404
Location:165 → 357

RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

pfam13716
Location:8 → 132

CRAL_TRIO_2; Divergent CRAL/TRIO domain